It has been happening to me as well—lotion doesn’t seem to be cutting it.
The Wirecutter recommends these hand creams:
My girlfriend is a pediatric OT and is constantly washing her hands. I think she has a prescription from her dermatologist for the hand cream she uses, but I’ll ask what it is.
EDIT: She uses with Neutrogena Norwegian Formula Hand Cream with Tetrix Cream on top. Apparently, Tetrix keeps it on for about 15 washes.